Professor Matthew Mohr’s design career has included owning a web design business in Cleveland, working at NASA, and a decade in New York working with clients such as Samsung, Newsweek, Norma Kamali, the Multiple Sclerosis Research Center of New York, Rao's, and Bloomingdale’s. After moving to Columbus, he owned Wonder-Shirts Inc., a company dedicated to celebrating reading and children's book illustrators.

As an artist, Mohr is most noted for As We Are, a large-scale interactive sculpture in the Greater Columbus Convention Center, as featured in Designboom, Colossal, Huffington Post, CNN and many international publications. As of 2020, over 50,000 people have added their portrait to the sculpture dedicated to honoring diversity and examining humanity's relationship to social media. Mohr also holds a seat on the Columbus Arts Commission.

Mohr earned a Bachelor of Fine Arts in Design from Bowling Green State University in 1990 and a Master of Fine Arts in Design and Technology from the Parsons New School for Design in 2003.